The Hotel San Luca is found in Cortona, situated in the center of the Valdichiana. Cortona is easily reachable:
Exit the Autostrada del Sole (A1) at the Valdichiana tollbooth. Immediately after exiting the toll booth, take the E45 highway (Siena-Perugia junction) towards Perugia and take the second exit for Cortona (Cortona San Lorenzo). From here it will be enough to follow the already numerous indications for Cortona in order to arrive at the SS71 in the locality of Camucia, deviating for Cortona-Città di Castello.
If you arrive by train at the stations of Camucia, Terontola, Arezzo or Castiglion Fiorentino, you can reach Cortona with the bus service.